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Proceedings Paper

Bidimensional assemblies of nonspherical gold nanoparticles for SERS analysis of biomolecules
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Paper Abstract

Direct SERS analysis of proteins has been mainly devoted to the characterization of short peptide fragments or to the prosthetic group of metallo-proteins due to their strong SERS response. Nonetheless, this perspective restricts the investigation to very limited peptide sequences and appears of scarce interest for a thorough characterization of the protein. We tried to overcome the above limitations by setting-up an effective platform for the structural SERS detection of proteins. Our proposal escapes the needs of a preliminary modification of the biomolecule and confers rapidity and reproducibility to the analysis. Optimal results are achieved by the use of nonspherical tipped metallic nanostructures with controlled architectural parameters and their assembly into organized bidimensional arrays including a regular distribution of hot spots for protein entrapment and detection. The investigation evidenced that both the contact points between nanoparticle corners and the holes at the interface between nanoparticles are responsible for substantial SERS activity.

Paper Details

Date Published: 11 March 2015
PDF: 5 pages
Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 93400S (11 March 2015); doi: 10.1117/12.2078659
Show Author Affiliations
Paolo Matteini, Institute of Applied Physics "Nello Carrara" (Italy)
Marella de Angelis, Institute of Applied Physics "Nello Carrara" (Italy)
Lorenzo Ulivi, Istituto dei Sistemi Complessi (Italy)
Sonia Centi, Univ. of Florence (Italy)
Roberto Pini, Institute of Applied Physics "Nello Carrara" (Italy)

Published in SPIE Proceedings Vol. 9340:
Plasmonics in Biology and Medicine XII
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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