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Proceedings Paper

Stamping SERS for creatinine sensing
Author(s): Ming Li; Yong Du; Fusheng Zhao; Jianbo Zeng; Greggy M. Santos; Chandra Mohan; Wei-Chuan Shih
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Paper Abstract

Urine can be obtained easily, readily and non-invasively. The analysis of urine can provide metabolic information of the body and the condition of renal function. Creatinine is one of the major components of human urine associated with muscle metabolism. Since the content of creatinine excreted into urine is relatively constant, it is used as an internal standard to normalize water variations. Moreover, the detection of creatinine concentration in urine is important for the renal clearance test, which can monitor the filtration function of kidney and health status. In more details, kidney failure can be imminent when the creatinine concentration in urine is high. A simple device and protocol for creatinine sensing in urine samples can be valuable for point-of-care applications. We reported quantitative analysis of creatinine in urine samples by using stamping surface enhanced Raman scattering (S-SERS) technique with nanoporous gold disk (NPGD) based SERS substrate. S-SERS technique enables label-free and multiplexed molecular sensing under dry condition, while NPGD provides a robust, controllable, and high-sensitivity SERS substrate. The performance of S-SERS with NGPDs is evaluated by the detection and quantification of pure creatinine and creatinine in artificial urine within physiologically relevant concentration ranges.

Paper Details

Date Published: 11 March 2015
PDF: 5 pages
Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 934004 (11 March 2015); doi: 10.1117/12.2078530
Show Author Affiliations
Ming Li, Univ. of Houston (United States)
Yong Du, Univ. of Houston (United States)
Fusheng Zhao, Univ. of Houston (United States)
Jianbo Zeng, Univ. of Houston (United States)
Greggy M. Santos, Univ. of Houston (United States)
Chandra Mohan, Univ. of Houston (United States)
Wei-Chuan Shih, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 9340:
Plasmonics in Biology and Medicine XII
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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