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Proceedings Paper

Monte Carlo modeling of light propagation in the human head for applications in sinus imaging
Author(s): Albert E. Cerussi; Nikhil Mishra; Joon You; Naveen Bhandarkar M.D.; Brian J. F. Wong M.D.
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Paper Abstract

Sinus blockages are a common reason for physician visits, affecting 1 out of 7 in the United States. Over 20 million cases of acute bacterial sinusitis become chronic and require medical treatment. Diagnosis in the primary care setting is challenging because symptom criteria (via detailed clinical history) plus objective imaging (CT or endoscopy) is recommended. Unfortunately, neither option is routinely available in primary care. Our previous work demonstrated that low-cost near infrared (NIR) transillumination instruments produced signals that correlated with the bulk findings of sinus opacity measured by CT. We have upgraded the technology, but questions remain such as finding the optimal arrangement of light sources, measuring the influence of specific anatomical structures, and determining detection limits. In order to begin addressing these questions, we have modeled NIR light propagation inside the adult human head using a mesh-based Monte Carlo algorithm (MMCLab) applied to a detailed anatomical head model constructed from CT images. In this application the sinus itself, which under healthy conditions is a void region (e.g., non-scattering), is the region of interest instead of an obstacle to other contrast mechanisms. We report preliminary simulations that characterize the changes in detected intensity due to clear (i.e., healthy) versus blocked sinuses. We also ran simulations for two of our clinical cases and compared results with the measurements. The simulations presented herein serve as a proof of concept that this approach could be used to understand contrast mechanisms and limitations of NIR imaging of the sinus cavities.

Paper Details

Date Published: 26 February 2015
PDF: 10 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93031Q (26 February 2015); doi: 10.1117/12.2078448
Show Author Affiliations
Albert E. Cerussi, Beckman Laser Institute and Medical Clinic (United States)
Nikhil Mishra, Northwood High School (United States)
Beckman Laser Institute and Medical Clinic (United States)
Joon You, Praxis BioSciences, Inc. (United States)
Naveen Bhandarkar M.D., Univ. of California, Irvine School of Medicine (United States)
Brian J. F. Wong M.D., Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine School of Medicine (United States)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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