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Proceedings Paper

Characterization of bone microstructure using photoacoustic spectrum analysis
Author(s): Ting Feng; Kenneth M. Kozloff; Guan Xu; Sidan Du; Jie Yuan; Cheri X. Deng; Xueding Wang
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Paper Abstract

Osteoporosis is a progressive bone disease that is characterized by a decrease in bone mass and deterioration in microarchitecture. This study investigates the feasibility of characterizing bone microstructure by analyzing the frequency spectrum of the photoacoustic signals from the bone. Modeling and numerical simulation of photoacoustic signals and their frequency-domain analysis were performed on trabecular bones with different mineral densities. The resulting quasilinear photoacoustic spectra were fit by linear regression, from which spectral parameter slope can be quantified. The modeling demonstrates that, at an optical wavelength of 685 nm, bone specimens with lower mineral densities have higher slope. Preliminary experiment on osteoporosis rat tibia bones with different mineral contents has also been conducted. The finding from the experiment has a good agreement with the modeling, both demonstrating that the frequency-domain analysis of photoacoustic signals can provide objective assessment of bone microstructure and deterioration. Considering that photoacoustic measurement is non-ionizing, non-invasive, and has sufficient penetration in both calcified and noncalcified tissues, this new technology holds unique potential for clinical translation.

Paper Details

Date Published: 11 March 2015
PDF: 6 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93234I (11 March 2015); doi: 10.1117/12.2078258
Show Author Affiliations
Ting Feng, Univ. of Michigan (United States)
Nanjing Univ. (China)
Kenneth M. Kozloff, Univ. of Michigan (United States)
Guan Xu, Univ. of Michigan (United States)
Sidan Du, Nanjing Univ. (China)
Jie Yuan, Nanjing Univ. (China)
Cheri X. Deng, Univ. of Michigan (United States)
Xueding Wang, Univ. of Michigan (United States)

Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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