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Proceedings Paper

Optical diagnosis of mammary ductal carcinoma using advanced optical technology
Author(s): Yan Wu; Fangmeng Fu; Yuane Lian; Yuting Nie; Shuangmu Zhuo; Chuan Wang; Jianxin Chen
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Paper Abstract

Clinical imaging techniques for diagnosing breast cancer mainly include X-ray mammography, ultrasound, and magnetic resonance imaging (MRI), which have respective drawbacks. Multiphoton microscopy (MPM) has become a potentially attractive optical technique to bridge the current gap in clinical utility. In this paper, MPM was used to image normal and ductal cancerous breast tissues, based on two-photon excited fluorescence (TPEF) and second harmonic generation (SHG). Our results showed that MPM has the ability to exhibit the microstructure of normal breast tissue, ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) lesions at the molecular level comparable to histopathology. These findings indicate that, with integration of MPM into currently accepted clinical imaging system, it has the potential to make a real-time histological diagnosis of mammary ductal carcinoma in vivo.

Paper Details

Date Published: 26 February 2015
PDF: 7 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032P (26 February 2015); doi: 10.1117/12.2078066
Show Author Affiliations
Yan Wu, Fujian Normal Univ. (China)
Jimei Univ. (China)
Fangmeng Fu, The Affiliated Union Hospital of Fujian Medical Univ. (China)
Yuane Lian, The Affiliated Union Hospital of Fujian Medical Univ. (China)
Yuting Nie, Fujian Normal Univ. (China)
Shuangmu Zhuo, Fujian Normal Univ. (China)
Chuan Wang, The Affiliated Union Hospital of Fujian Medical Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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