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Proceedings Paper

Photodynamic therapy as a new approach in vulvovaginal candidiasis in murine model
Author(s): Maria E. Santi M.D.; Rubia G. Lopes; Renato A. Prates; Aline Sousa; Luis R. Ferreira; Adjaci U. Fernandes; Sandra K. Bussadori; Alessandro M. Deana
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Paper Abstract

Vulvovaginal candidiasis is a common cause of vaginal infections. This study investigates the efficiency of antimicrobial photodynamic therapy (aPDT) against yeast cells in mice. Methylene blue (MB), malachite green (MG), and a special designed protoporphirin (PpNetNI) were used as photosensitizers. Female BALB-c mice were infected with Candida albicans ATCC 90028. PDT was applied with two different light sources, intravaginal and transabdominal. Vaginal washes were performed and cultivated for microbial quantification. Antimicrobial PDT was able to decrease microbial content with MB and PpNetNI (p<0.05), it was not effective, however, with MG photosensitizer. The results of this study demonstrate that aPDT may be a viable alternative treatment for vaginal candidiasis.

Paper Details

Date Published: 26 February 2015
PDF: 5 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032H (26 February 2015); doi: 10.1117/12.2078014
Show Author Affiliations
Maria E. Santi M.D., Nove de Julho Univ. (Brazil)
Rubia G. Lopes, Nove de Julho Univ. (Brazil)
Renato A. Prates, Nove de Julho Univ. (Brazil)
Aline Sousa, Nove de Julho Univ. (Brazil)
Luis R. Ferreira, Nove de Julho Univ. (Brazil)
Adjaci U. Fernandes, Univ. Camilo Castelo Branco (Brazil)
Sandra K. Bussadori, Nove de Julho Univ. (Brazil)
Alessandro M. Deana, Nove de Julho Univ. (Brazil)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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