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Proceedings Paper

Treating cutaneous squamous cell carcinoma using ALA PLGA nanoparticle-mediated photodynamic therapy in a mouse model
Author(s): Xiaojie Wang; Lei Shi; Qingfeng Tu; Hongwei Wang; Haiyan Zhang; Peiru Wang; Linglin Zhang; Zheng Huang; Xiuli Wang; Feng Zhao; Hansen Luan
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Paper Abstract

Background: Squamous cell carcinoma (SCC) is a common skin cancer and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted ALA delivery for topical photodynamic therapy (PDT) of cutaneous SCC.

Methods: UV-induced cutaneous SCCs were established in hairless mice. ALA loaded polylactic-co-glycolic acid (PLGA) NPs were prepared and characterized. The kinetics of ALA PLGA NPs-induced protoporphyrin IX (PpIX) fluorescence in SCCs, therapeutic efficacy of ALA NP-mediated PDT, and immune responses were examined.

Results: PLGA NPs could enhance PpIX production in SCC. ALA PLGA NP mediated topical PDT was more effective than free ALA of the same concentration in treating cutaneous SCC.

Conclusion: PLGA NPs provide a promising strategy for delivering ALA in topical PDT of cutaneous SCC.

Paper Details

Date Published: 9 March 2015
PDF: 12 pages
Proc. SPIE 9324, Biophotonics and Immune Responses X, 93240U (9 March 2015); doi: 10.1117/12.2077939
Show Author Affiliations
Xiaojie Wang, Shanghai Dermatology Hospital (China)
Lei Shi, Shanghai Skin Disease Hospital (China)
Qingfeng Tu, Shanghai Skin Disease Hospital (China)
Hongwei Wang, Fudan Univ. (China)
Haiyan Zhang, Shanghai Skin Disease Hospital (China)
Peiru Wang, Shanghai Skin Disease Hospital (China)
Linglin Zhang, Shanghai Skin Disease Hospital (China)
Zheng Huang, Fujian Normal Univ. (China)
Xiuli Wang, Shanghai Skin Disease Hospital (China)
Feng Zhao, China State Institute of Pharmaceutical Industry (China)
Hansen Luan, China State Institute of Pharmaceutical Industry (China)

Published in SPIE Proceedings Vol. 9324:
Biophotonics and Immune Responses X
Wei R. Chen, Editor(s)

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