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Proceedings Paper

Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer
Author(s): Shaozhen Song; Nhan Minh Le; Ruikang K. Wang; Zhihong Huang
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Paper Abstract

Shear Wave Optical Coherence Elastography (SW-OCE) uses the speed of propagating shear waves to provide a quantitative measurement of localized shear modulus, making it a valuable technique for the elasticity characterization of tissues such as skin and ocular tissue. One of the main challenges in shear wave elastography is to induce a reliable source of shear wave; most of nowadays techniques use external vibrators which have several drawbacks such as limited wave propagation range and/or difficulties in non-invasive scans requiring precisions, accuracy. Thus, we propose linear phase array ultrasound transducer as a remote wave source, combined with the high-speed, 47,000-frame-per-second Shear-wave visualization provided by phase-sensitive OCT. In this study, we observed for the first time shear waves induced by a 128 element linear array ultrasound imaging transducer, while the ultrasound and OCT images (within the OCE detection range) were triggered simultaneously. Acoustic radiation force impulses are induced by emitting 10 MHz tone-bursts of sub-millisecond durations (between 50 μm – 100 μm). Ultrasound beam steering is achieved by programming appropriate phase delay, covering a lateral range of 10 mm and full OCT axial (depth) range in the imaging sample. Tissue-mimicking phantoms with agarose concentration of 0.5% and 1% was used in the SW-OCE measurements as the only imaging samples. The results show extensive improvements over the range of SW-OCE elasticity map; such improvements can also be seen over shear wave velocities in softer and stiffer phantoms, as well as determining the boundary of multiple inclusions with different stiffness. This approach opens up the feasibility to combine medical ultrasound imaging and SW-OCE for high-resolution localized quantitative measurement of tissue biomechanical property.

Paper Details

Date Published: 6 March 2015
PDF: 5 pages
Proc. SPIE 9327, Optical Elastography and Tissue Biomechanics II, 93270U (6 March 2015); doi: 10.1117/12.2077931
Show Author Affiliations
Shaozhen Song, Univ. of Dundee (United Kingdom)
Univ. of Washington (United States)
Nhan Minh Le, Univ. of Dundee (United Kingdom)
Ruikang K. Wang, Univ. of Washington (United States)
Zhihong Huang, Univ. of Dundee (United Kingdom)

Published in SPIE Proceedings Vol. 9327:
Optical Elastography and Tissue Biomechanics II
Kirill V. Larin; David D. Sampson, Editor(s)

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