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Proceedings Paper

A multimodal imaging agent for intrinsic surface enhanced Raman scattering of biological tissue
Author(s): C. B. Pohling; J. L. Campbell; Timothy A. Larson; S. S. Gambhir M.D.
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Paper Abstract

Raman imaging is an optical method that provides chemo-selective contrast, microscopic resolution and multiplexing capability. Medical applications, however, still suffer from weak signals and resulting long acquisition times. Plasmon resonance effects can drastically increase signals for Surface Enhanced Raman Scattering (SERS). Here, we present concepts towards an ideal, multimodal SERS agent for medical applications. Enhancement of intrinsic spectra of biological tissue is combined with contrast in Photoacoustic- and Magnetic Resonance Tomography, making this imaging agent highly promising for clinical radiology.

Paper Details

Date Published: 11 March 2015
PDF: 8 pages
Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 93400A (11 March 2015); doi: 10.1117/12.2077890
Show Author Affiliations
C. B. Pohling, Stanford School of Medicine (United States)
J. L. Campbell, Stanford School of Medicine (United States)
Timothy A. Larson, Stanford Univ. (United States)
S. S. Gambhir M.D., Stanford School of Medicine (United States)

Published in SPIE Proceedings Vol. 9340:
Plasmonics in Biology and Medicine XII
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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