
Proceedings Paper
In vivo outcome study of BPD-mediated PDT using a macroscopic singlet oxygen modelFormat | Member Price | Non-Member Price |
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Paper Abstract
Macroscopic modeling of the apparent reacted singlet oxygen concentration ([1O2]rx) for use with photodynamic
therapy (PDT) has been developed and studied for benzoporphryin derivative monoacid ring A (BPD), a common
photosensitizer. The four photophysical parameters (ξ, σ, β, δ) and threshold singlet oxygen dose ([1O2]rx, sh) have
been investigated and determined using the RIF model of murine fibrosarcomas and interstitial treatment delivery.
These parameters are examined and verified further by monitoring tumor growth post-PDT. BPD was administered
at 1 mg/kg, and mice were treated 3 hours later with fluence rates ranging between 75 – 150 mW/cm2 and total
fluences of 100 – 350 J/cm2. Treatment was delivered superficially using a collimated beam. Changes in tumor
volume were tracked following treatment. The tumor growth rate was fitted for each treatment condition group and
compared using dose metrics including total light dose, PDT dose, and reacted singlet oxygen. Initial data showing
the correlation between outcomes and various dose metrics indicate that reacted singlet oxygen serves as a good
dosimetric quantity for predicting PDT outcome.
Paper Details
Date Published: 2 March 2015
PDF: 8 pages
Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 93080A (2 March 2015); doi: 10.1117/12.2077803
Published in SPIE Proceedings Vol. 9308:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV
David H. Kessel; Tayyaba Hasan, Editor(s)
PDF: 8 pages
Proc. SPIE 9308, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, 93080A (2 March 2015); doi: 10.1117/12.2077803
Show Author Affiliations
Michele M. Kim, The Univ. of Pennsylvania Health System (United States)
Univ. of Pennsylvania (United States)
Rozhin Penjweini, The Univ. of Pennsylvania Health System (United States)
Univ. of Pennsylvania (United States)
Rozhin Penjweini, The Univ. of Pennsylvania Health System (United States)
Timothy C. Zhu, The Univ. of Pennsylvania Health System (United States)
Published in SPIE Proceedings Vol. 9308:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV
David H. Kessel; Tayyaba Hasan, Editor(s)
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