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Proceedings Paper

Characterization of human cervical remodeling throughout pregnancy using in vivo Raman spectroscopy
Author(s): Christine M. O'Brien; Elizabeth Vargis; Chris Slaughter; Amy P Rudin; Jennifer L. Herington; Kelly A. Bennett; Jeff Reese; Anita Mahadevan-Jansen
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Paper Abstract

Globally, fifteen million babies are born preterm each year, affecting 1 in 8 pregnancies in the US alone. Cervical remodeling includes a biochemical cascade of changes that ultimately result in the thinning and dilation of the cervix for passage of a fetus. This process is poorly understood and is the focus of this study. Our group is utilizing Raman spectroscopy to evaluate biochemical changes occurring in the human cervix throughout pregnancy. This technique has high molecular specificity and can be performed in vivo, with the potential to unveil new molecular dynamics essential for cervical remodeling.

Paper Details

Date Published: 9 March 2015
PDF: 6 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93032F (9 March 2015); doi: 10.1117/12.2077775
Show Author Affiliations
Christine M. O'Brien, Vanderbilt Univ. (United States)
Elizabeth Vargis, Vanderbilt Univ. (United States)
Utah State Univ. (United States)
Chris Slaughter, Vanderbilt Univ. Medical Ctr. (United States)
Amy P Rudin, Vanderbilt Univ (United States)
Jennifer L. Herington, Vanderbilt Univ. Medical Ctr. (United States)
Kelly A. Bennett, Vanderbilt Univ. Medical Ctr. (United States)
Jeff Reese, Vanderbilt Univ. Medical Ctr. (United States)
Anita Mahadevan-Jansen, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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