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Proceedings Paper

Full-field OCT for fast diagnostic of head and neck cancer
Author(s): Frederic De Leeuw; Odile Casiraghi; Aïcha Ben Lakhdar ; Muriel Abbaci; Corinne Laplace-Builhé
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Paper Abstract

Full-Field OCT (FFOCT) produces optical slices of tissue using white light interferometry providing in-depth 2D images, with an isotropic resolution around 1 micrometer. These optical biopsy images are similar to those obtained with established histological procedures, but without tissue preparation and within few minutes. This technology could be useful when diagnosing a lesion or at the time of its surgical management.

Here we evaluate the clinical value of FFOCT imaging in the management of patients with Head and Neck cancers by assessing the accuracy of the diagnosis done on FFOCT images from resected specimen.

FFOCT images from Head and Neck samples were first compared to the gold standard (HES-conventional histology). An image atlas dedicated to the training of pathologists was built and diagnosis criteria were identified.

Then, we performed a morphological correlative study: both healthy and cancerous samples from patients who undergo Head and Neck surgery of oral cavity, pharynx, and larynx were imaged. Images were interpreted in a random way by two pathologists and the FFOCT based diagnostics were compared with HES (gold standard) of the same samples.

Here we present preliminary results showing that FFOCT provides a quick assessment of tissue architecture at microscopic level that could guide surgeons for tumor margin delineation during intraoperative procedure.

Paper Details

Date Published: 26 February 2015
PDF: 8 pages
Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 93031Z (26 February 2015); doi: 10.1117/12.2077664
Show Author Affiliations
Frederic De Leeuw, Institut Gustave Roussy (France)
Univ. Paris-Sud, CNRS, IR4M (France)
Odile Casiraghi, Institut Gustave Roussy (France)
Aïcha Ben Lakhdar , Institut Gustave Roussy (France)
Muriel Abbaci, Institut Gustave Roussy (France)
Univ. Paris-Sud, CNRS, IR4M (France)
Corinne Laplace-Builhé, Institut Gustave Roussy (France)
Univ. Paris-Sud, CNRS, IR4M (France)

Published in SPIE Proceedings Vol. 9303:
Photonic Therapeutics and Diagnostics XI
Hyun Wook Kang; Brian J. F. Wong M.D.; Melissa C. Skala; Bernard Choi; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Mark W. Dewhirst D.V.M.; Justus F. Ilgner M.D.; Alfred Nuttal; Haishan Zeng; Laura Marcu; Claus-Peter Richter, Editor(s)

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