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Proceedings Paper

Assessing carotid atherosclerosis by fiber-optic multispectral photoacoustic tomography
Author(s): Jie Hui; Rui Li; Pu Wang; Evan Phillips; Rebecca Bruning; Chien-Sheng Liao; Michael Sturek; Craig J. Goergen; Ji-Xin Cheng
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Paper Abstract

Atherosclerotic plaque at the carotid bifurcation is the underlying cause of the majority of ischemic strokes. Noninvasive imaging and quantification of the compositional changes preceding gross anatomic changes within the arterial wall is essential for diagnosis of disease. Current imaging modalities such as duplex ultrasound, computed tomography, positron emission tomography are limited by the lack of compositional contrast and the detection of flow-limiting lesions. Although high-resolution magnetic resonance imaging has been developed to characterize atherosclerotic plaque composition, its accessibility for wide clinical use is limited. Here, we demonstrate a fiber-based multispectral photoacoustic tomography system for excitation of lipids and external acoustic detection of the generated ultrasound. Using sequential ultrasound imaging of ex vivo preparations we achieved ~2 cm imaging depth and chemical selectivity for assessment of human arterial plaques. A multivariate curve resolution alternating least squares analysis method was applied to resolve the major chemical components, including intravascular lipid, intramuscular fat, and blood. These results show the promise of detecting carotid plaque in vivo through esophageal fiber-optic excitation of lipids and external acoustic detection of the generated ultrasound. This imaging system has great potential for serving as a point-ofcare device for early diagnosis of carotid artery disease in the clinic.

Paper Details

Date Published: 11 March 2015
PDF: 7 pages
Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 93233S (11 March 2015); doi: 10.1117/12.2076999
Show Author Affiliations
Jie Hui, Purdue Univ. (United States)
Rui Li, Purdue Univ. (United States)
Pu Wang, Purdue Univ. (United States)
Evan Phillips, Purdue Univ. (United States)
Rebecca Bruning, Indiana Univ. School of Medicine (United States)
Chien-Sheng Liao, Purdue Univ. (United States)
Michael Sturek, Purdue Univ. (United States)
Indiana Univ. School of Medicine (United States)
Craig J. Goergen, Purdue Univ. (United States)
Ji-Xin Cheng, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 9323:
Photons Plus Ultrasound: Imaging and Sensing 2015
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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