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Proceedings Paper

In vivo laser-based imaging of the human fallopian tube for future cancer detection
Author(s): Eric J. Seibel; Charles D. Melville; Richard S. Johnston; Yuanzheng Gong; Kathy Agnew; Seine Chiang; Elizabeth M. Swisher
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Paper Abstract

Inherited mutations in BRCA1 and BRCA2 lead to 20-50% lifetime risk of ovarian, tubal, or peritoneal carcinoma. Clinical recommendations for women with these genetic mutations include the prophylactic removal of ovaries and fallopian tubes by age 40 after child-bearing. Recent findings suggest that many presumed ovarian or peritoneal carcinomas arise in fallopian tube epithelium. Although survival rate is <90% when ovarian cancer is detected early (Stage_I), 70% of women have advanced disease (Stage_III/IV) at presentation when survival is less than 30%. Over the years, effective early detection of ovarian cancer has remained elusive, possibly because screening techniques have mistakenly focused on the ovary as origin of ovarian carcinoma. Unlike ovaries, the fallopian tubes are amenable to direct visual imaging without invasive surgery, using access through the cervix. To develop future screening protocols, we investigated using our 1.2- mm diameter, forward-viewing, scanning fiber endoscope (SFE) to image luminal surfaces of the fallopian tube before laparoscopic surgical removal. Three anesthetized human subjects participated in our protocol development which eventually led to 70-80% of the length of fallopian tubes being imaged in scanning reflectance, using red (632nm), green (532nm), and blue (442nm) laser light. A hysteroscope with saline uterine distention was used to locate the tubal ostia. To facilitate passage of the SFE through the interstitial portion of the fallopian tube, an introducer catheter was inserted 1- cm through each ostia. During insertion, saline was flushed to reduce friction and provide clearer viewing. This is likely the first high-resolution intraluminal visualization of fallopian tubes.

Paper Details

Date Published: 2 March 2015
PDF: 9 pages
Proc. SPIE 9304, Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II, 93040Q (2 March 2015); doi: 10.1117/12.2076972
Show Author Affiliations
Eric J. Seibel, Univ. of Washington (United States)
Charles D. Melville, Univ. of Washington (United States)
Richard S. Johnston, Univ. of Washington (United States)
Yuanzheng Gong, Univ. of Washington (United States)
Kathy Agnew, Obstrectrics and Gynecology (United States)
Seine Chiang, Obstrectrics and Gynecology (United States)
Elizabeth M. Swisher, Obstrectrics and Gynecology (United States)

Published in SPIE Proceedings Vol. 9304:
Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II
Melissa J. Suter; Guillermo J. Tearney M.D.; Thomas D. Wang; Stephen Lam M.D.; Matthew Brenner, Editor(s)

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