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Proceedings Paper

An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events
Author(s): Esmaeil Heydari; David Thompson; Duncan Graham; Jonathan M. Cooper; Alasdair W. Clark
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Paper Abstract

We report a versatile nanophotonic biosensing platform that enables both colorimetric detection and enhanced Raman spectroscopy detection of molecular binding events. Through the integration of electron-beam lithography, dip-pennanolithography and molecular self-assembly, we demonstrate plasmonic nanostructures which change geometry and plasmonic properties in response to molecularly-mediated nanoparticle binding events. These biologically-active nanostructured surfaces hold considerable potential for use as multiplexed sensor platforms for point-of-care diagnostics, and as scaffolds for a new generation of molecularly dynamic metamaterials.

Paper Details

Date Published: 11 March 2015
PDF: 6 pages
Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 93400O (11 March 2015); doi: 10.1117/12.2076915
Show Author Affiliations
Esmaeil Heydari, Univ. of Glasgow (United Kingdom)
David Thompson, Univ. of Strathclyde (United Kingdom)
Duncan Graham, Univ. of Strathclyde (United Kingdom)
Jonathan M. Cooper, Univ. of Glasgow (United Kingdom)
Alasdair W. Clark, Univ. of Glasgow (United Kingdom)

Published in SPIE Proceedings Vol. 9340:
Plasmonics in Biology and Medicine XII
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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