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Proceedings Paper

DNA origami based assembly of gold nanoparticle dimers for SERS detection
Author(s): Vivek V. Thacker; Lars O. Herrmann; Daniel O. Sigle; Tao Zhang; Tim Liedl; Jeremy J. Baumberg; Ulrich F. Keyser
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Paper Abstract

Plasmonic sensors are extremely promising candidates for label-free single molecule analysis but require exquisite control over the physical arrangement of metallic nanostructures. We employ self-assembly based on the DNA origami technique for accurate positioning of individual 40 nm gold nanoparticles with gaps of 3.3±1 nm. This is probed through far field scattering measurements on individual dimers. This plasmonic coupling allows us to use surface enhanced Raman scattering (SERS) to detect a small number of dye molecules as well as short single-stranded DNA oligonucleotides in the vicinity of the dimers. This demonstrates that DNA origami is a powerful tool with great potential for a wide variety of biosensing and single-molecule applications.

Paper Details

Date Published: 11 March 2015
PDF: 8 pages
Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 934002 (11 March 2015); doi: 10.1117/12.2076799
Show Author Affiliations
Vivek V. Thacker, Univ. of Cambridge (United Kingdom)
Lars O. Herrmann, Univ. of Cambridge (United Kingdom)
Daniel O. Sigle, Univ. of Cambridge (United Kingdom)
Tao Zhang, Ludwig-Maximilians-Univ. München (Germany)
Tim Liedl, Ludwig-Maximilians-Univ. München (Germany)
Jeremy J. Baumberg, Univ. of Cambridge (United Kingdom)
Ulrich F. Keyser, Univ. of Cambridge (United Kingdom)

Published in SPIE Proceedings Vol. 9340:
Plasmonics in Biology and Medicine XII
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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