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Proceedings Paper

Microscopic x-ray luminescence computed tomography
Author(s): Wei Zhang; Dianwen Zhu; Kun Zhang; Changqing Li
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Paper Abstract

X-ray luminescence computed tomography (XLCT) was emerged as a new hybrid imaging modality, in which the x-rays are used to excite phosphors emitting optical photons to be measured for imaging. In this paper, we reported a microscopic x-ray luminescence computed tomography (microXLCT) with a spatial resolution up to hundreds of micrometers for deep targets. We use a superfine x-ray pencil beam to scan the phosphor targets. The superfine x-ray pencil beam is generated by a small collimator mounted in front of a powerful x-ray tube (93212, Oxford Instrument). A CT detector is used to image the x-ray beam. We have generated an x-ray beam with a diameter of 192 micrometers with a collimator of 100 micrometers in diameter. The emitted optical photons on the top surface of phantom are reflected by a mirror and acquired by an electron multiplier charge-coupled device (EMCCD) camera (C9100-13, Hamamatsu Photonics). The microXLCT imaging system is built inside an x-ray shielding and light tight cabinet. The EMCCD camera is placed in a lead box. All the imaging components are controlled by a VC++ program. The optical photon propagation is modeled with the diffusion equation solved by the finite element method. We have applied different regularization methods including L2 and L1 in the microXLCT reconstruction algorithms. Numerical simulations and phantom experiments are used to validate the microXLCT imaging system.

Paper Details

Date Published: 12 March 2015
PDF: 6 pages
Proc. SPIE 9316, Multimodal Biomedical Imaging X, 93160M (12 March 2015); doi: 10.1117/12.2076797
Show Author Affiliations
Wei Zhang, Univ. of California, Merced (United States)
Dianwen Zhu, Univ. of California, Merced (United States)
Kun Zhang, Univ. of California, Merced (United States)
Changqing Li, Univ. of California, Merced (United States)

Published in SPIE Proceedings Vol. 9316:
Multimodal Biomedical Imaging X
Fred S. Azar; Xavier Intes, Editor(s)

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