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Proceedings Paper

Sentinel lymph node detection in breast cancer patients using surgical navigation system based on fluorescence molecular imaging technology
Author(s): Chongwei Chi; Deqiang Kou; Jinzuo Ye; Yamin Mao; Jingdan Qiu; Jiandong Wang; Xin Yang; Jie Tian
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Paper Abstract

Introduction: Precision and personalization treatments are expected to be effective methods for early stage cancer studies. Breast cancer is a major threat to women’s health and sentinel lymph node biopsy (SLNB) is an effective method to realize precision and personalized treatment for axillary lymph node (ALN) negative patients. In this study, we developed a surgical navigation system (SNS) based on optical molecular imaging technology for the precise detection of the sentinel lymph node (SLN) in breast cancer patients. This approach helps surgeons in precise positioning during surgery.

Methods: The SNS was mainly based on the technology of optical molecular imaging. A novel optical path has been designed in our hardware system and a feature-matching algorithm has been devised to achieve rapid fluorescence and color image registration fusion. Ten in vivo studies of SLN detection in rabbits using indocyanine green (ICG) and blue dye were executed for system evaluation and 8 breast cancer patients accepted the combination method for therapy.

Results: The detection rate of the combination method was 100% and an average of 2.6 SLNs was found in all patients. Our results showed that the method of using SNS to detect SLN has the potential to promote its application.

Conclusion: The advantage of this system is the real-time tracing of lymph flow in a one-step procedure. The results demonstrated the feasibility of the system for providing accurate location and reliable treatment for surgeons. Our approach delivers valuable information and facilitates more detailed exploration for image-guided surgery research.

Paper Details

Date Published: 4 March 2015
PDF: 7 pages
Proc. SPIE 9311, Molecular-Guided Surgery: Molecules, Devices, and Applications, 93110V (4 March 2015); doi: 10.1117/12.2076517
Show Author Affiliations
Chongwei Chi, Key Lab. of Molecular Imaging (China)
Deqiang Kou, The General Hospital of People’s Liberation Army (China)
Jinzuo Ye, Key Lab. of Molecular Imaging (China)
Yamin Mao, Key Lab. of Molecular Imaging (China)
Jingdan Qiu, The General Hospital of People’s Liberation Army (China)
Jiandong Wang, The General Surgery Ctr., People's Liberation Army General Hospital (China)
Xin Yang, Key Lab. of Molecular Imaging (China)
Jie Tian, Key Lab. of Molecular Imaging (China)

Published in SPIE Proceedings Vol. 9311:
Molecular-Guided Surgery: Molecules, Devices, and Applications
Brian W. Pogue; Sylvain Gioux, Editor(s)

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