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Proceedings Paper

Multifunctional iron oxide nanoparticles for biomedical applications
Author(s): M. Bloemen; Carla Denis; Thomas Van Stappen; L. De Meester; N. Geukens; A. Gils; T. Verbiest
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Paper Abstract

Multifunctional nanoparticles have attracted a lot of attention since they can combine interesting properties like magnetism, fluorescence or plasmonic effects. As a core material, iron oxide nanoparticles have been the subject of intensive research. These cost-effective and non-toxic particles are used nowadays in many applications. We developed a heterobifunctional PEG ligand that can be used to introduce functional groups (carboxylic acids) onto the surface of the NP. Via click chemistry, a siloxane functionality was added to this ligand, for a subsequent covalent ligand exchange reaction. The functionalized nanoparticles have an excellent colloidal stability in complex environments like buffers and serum or plasma. Antibodies were coupled to the introduced carboxylic acids and these NP-antibody bioconjugates were brought into contact with Legionella bacteria for magnetic separation experiments.

Paper Details

Date Published: 12 March 2015
PDF: 8 pages
Proc. SPIE 9338, Colloidal Nanoparticles for Biomedical Applications X, 933816 (12 March 2015); doi: 10.1117/12.2076120
Show Author Affiliations
M. Bloemen, Katholieke Univ. Leuven (Belgium)
Carla Denis, Katholieke Univ. Leuven (Belgium)
Thomas Van Stappen, Katholieke Univ. Leuven (Belgium)
L. De Meester, Katholieke Univ. Leuven (Belgium)
N. Geukens, Katholieke Univ. Leuven (Belgium)
A. Gils, Katholieke Univ. Leuven (Belgium)
T. Verbiest, Katholieke Univ. Leuven (Belgium)

Published in SPIE Proceedings Vol. 9338:
Colloidal Nanoparticles for Biomedical Applications X
Wolfgang J. Parak; Marek Osinski; Xing-Jie Liang, Editor(s)

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