
Proceedings Paper
Acquisition of priori tissue optical structure based on non-rigid image registrationFormat | Member Price | Non-Member Price |
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Paper Abstract
Shape-parameterized diffuse optical tomography (DOT), which is based on a priori that assumes the uniform distribution
of the optical properties in the each region, shows the effectiveness of complex biological tissue optical heterogeneities
reconstruction. The priori tissue optical structure could be acquired with the assistance of anatomical imaging methods
such as X-ray computed tomography (XCT) which suffers from low-contrast for soft tissues including different optical
characteristic regions. For the mouse model, a feasible strategy of a priori tissue optical structure acquisition is proposed
based on a non-rigid image registration algorithm. During registration, a mapping matrix is calculated to elastically align
the XCT image of reference mouse to the XCT image of target mouse. Applying the matrix to the reference atlas which
is a detailed mesh of organs/tissues in reference mouse, registered atlas can be obtained as the anatomical structure of
target mouse. By assigning the literature published optical parameters of each organ to the corresponding anatomical
structure, optical structure of the target organism can be obtained as a priori information for DOT reconstruction
algorithm. By applying the non-rigid image registration algorithm to a target mouse which is transformed from the
reference mouse, the results show that the minimum correlation coefficient can be improved from 0.2781 (before
registration) to 0.9032 (after fine registration), and the maximum average Euclid distances can be decreased from
12.80mm (before registration) to 1.02mm (after fine registration), which has verified the effectiveness of the algorithm.
Paper Details
Date Published: 5 March 2015
PDF: 8 pages
Proc. SPIE 9316, Multimodal Biomedical Imaging X, 93160O (5 March 2015); doi: 10.1117/12.2075710
Published in SPIE Proceedings Vol. 9316:
Multimodal Biomedical Imaging X
Fred S. Azar; Xavier Intes, Editor(s)
PDF: 8 pages
Proc. SPIE 9316, Multimodal Biomedical Imaging X, 93160O (5 March 2015); doi: 10.1117/12.2075710
Show Author Affiliations
Wenbo Wan, Tianjin Univ. (China)
Jiao Li, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)
Lingling Liu, Tianjin Univ. (China)
Jiao Li, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)
Lingling Liu, Tianjin Univ. (China)
Yihan Wang, Tianjin Univ. (China)
Yan Zhang, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)
Yan Zhang, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Tianjin Key Lab. of Biomedical Detecting Techniques and Instruments (China)
Published in SPIE Proceedings Vol. 9316:
Multimodal Biomedical Imaging X
Fred S. Azar; Xavier Intes, Editor(s)
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