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Proceedings Paper

RF heating of nanoclusters for cancer therapy
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Paper Abstract

Nanodrugs selectively delivered to a tumor site can be activated by radiation for drug release, or nanoparticles (NPs) can be used as a drug themselves by producing biological damage in cancer cells through thermal, mechanical ablations or charged particle emission. Radio-frequency (RF) waves have an excellent ability to penetrate into the human body without causing healthy tissue damage, which provides a great opportunity to activate/heat NPs delivered inside the body as a contrast agent for diagnosis and treatment purposes. However the heating of NPs in the RF range of the spectrum is controversial in the research community because of the low power load of RF waves and low absorption of NPs in the RF range. To resolve these weaknesses in the RF activation of NPs and dramatically increase absorption of contrast agents in tumor, we suggest aggregating the nanoclusters inside or on the surface of the cancer cells. We simulate space distribution of temperature changes inside and outside metal and dielectric nanopraticles/nanoclusters, determine the number of nanoparticles needed to form a cluster, and estimate the thermal damage area produced in surrounding medium by nanopraticles/nanoclusters heated in the RF field.

Paper Details

Date Published: 12 March 2015
PDF: 9 pages
Proc. SPIE 9338, Colloidal Nanoparticles for Biomedical Applications X, 93381G (12 March 2015);
Show Author Affiliations
Renat R. Letfullin, Rose-Hulman Institute of Technology (United States)
Alla R. Letfullin, Rose-Hulman Institute of Technology (United States)
Thomas F. George, Univ. of Missouri-St. Louis (United States)

Published in SPIE Proceedings Vol. 9338:
Colloidal Nanoparticles for Biomedical Applications X
Wolfgang J. Parak; Marek Osinski; Xing-Jie Liang, Editor(s)

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