Fluorescence molecular tomography (FMT) gains increasing interests in deep tissue imaging. Here we report a novel FMT system setup with full angel projections. In this system, a tungsten-halogen lamp is applied as illumination, while a scientific complementary metal oxide semiconductor (sCMOS) is used as a detecting device. With a unique line-pattern illumination and a high sensitivity sCMOS, our FMT system can complete data acquisition over 36 perspective angles along the animal within 10 minutes. We also employ a novel transparent animal bed, which is suitable to hold the animal for long time experiments. Both phantom and in vivo animal experiments have been studied, and our results demonstrate this FMT system has a great potential for small animal study. In addition, our design allows this FMT system to be easily applied in either stand-alone fluorescent systems or combined with other molecular imaging methods.

Date Published: 17 September 2014
PDF: 7 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923022 (17 September 2014); doi: 10.1117/12.2068919

Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)