
Proceedings Paper
Raman spectroscopy of human saliva for acute myocardial infarction detectionFormat | Member Price | Non-Member Price |
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Paper Abstract
Raman spectroscopy is a rapidly non-invasive technique with great potential for biomedical research. The aim of this
study was to evaluate the feasibility of using Raman spectroscopy of human saliva for acute myocardial infarction (AMI)
detection. Raman spectroscopy measurements were performed on two groups of saliva samples: one group from patients
(n=30) with confirmed AMI and the other group from healthy controls (n=31). The diagnostic performance for
differentiating AMI saliva from normal saliva was evaluated by multivariate statistical analysis. The combination of
principal component analysis (PCA) and linear discriminate analysis (LDA) of the measured Raman spectra separated
the spectral features of the two groups into two distinct clusters with little overlaps, rendering the sensitivity of 80.0%
and specificity of 80.6%. The results from this exploratory study demonstrated that Raman spectroscopy of human saliva
can serve as a potentially clinical tool for rapid AMI detection and screening.
Paper Details
Date Published: 17 September 2014
PDF: 5 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92300J (17 September 2014); doi: 10.1117/12.2068876
Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)
PDF: 5 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92300J (17 September 2014); doi: 10.1117/12.2068876
Show Author Affiliations
Maowen Chen, Fujian Normal Univ. (China)
Yuanxiang Chen, Fujian Medical Univ. (China)
Shanshan Wu, Fujian Normal Univ. (China)
Wei Huang, Fujian Normal Univ. (China)
Fujian Metrology Institute (China)
Yuanxiang Chen, Fujian Medical Univ. (China)
Shanshan Wu, Fujian Normal Univ. (China)
Wei Huang, Fujian Normal Univ. (China)
Fujian Metrology Institute (China)
Jinyong Lin, Fujian Normal Univ. (China)
Guo-Xing Weng, Fujian Medical Univ. (China)
Rong Chen, Fujian Normal Univ. (China)
Guo-Xing Weng, Fujian Medical Univ. (China)
Rong Chen, Fujian Normal Univ. (China)
Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)
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