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Proceedings Paper

Detection of gastrointestinal cancer by elastic scattering and absorption spectroscopies with the Los Alamos Optical Biopsy System
Author(s): Judith R. Mourant; James D. Boyer; Tamara M. Johnson; JoAnne Lacey; Irving J. Bigio; Anthony G. Bohorfoush; Mark H. Mellow
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Paper Abstract

The Los Alamos National Laboratory has continued the development of the Optical Biopsy System (OBS) for noninvasive, real-time in situ diagnosis of tissue pathologies. In proceedings of earlier SPIE conferences we reported on clinical measurements in the bladder, and we report here on recent results of clinical tests in the gastrointestinal tract. With the OBS, tissue pathologies are detected/diagnosed using spectral measurement of the elastic optical transport properties (scattering and absorption) of the tissue over a wide range of wavelengths. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, exhibit significant architectural changes at the cellular and subcellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes in an optical signature that is derived from the wavelength-dependence of elastic scattering. Additionally, the optical geometry of the OBS beneficially enhances its sensitivity for measuring absorption bands. The OBS employs a small fiber optic probe that is amenable to use with any endoscope or catheter, or to direct surface examination, as well as interstitial needle insertion. Data acquisition/display time is < 1 second.

Paper Details

Date Published: 12 April 1995
PDF: 8 pages
Proc. SPIE 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, (12 April 1995); doi: 10.1117/12.206824
Show Author Affiliations
Judith R. Mourant, Los Alamos National Lab. (United States)
James D. Boyer, Los Alamos National Lab. (United States)
Tamara M. Johnson, Los Alamos National Lab. (United States)
JoAnne Lacey, Los Alamos National Lab. (United States)
Irving J. Bigio, Los Alamos National Lab. (United States)
Anthony G. Bohorfoush, Wisconsin Medical School (United States)
Mark H. Mellow, Univ. of Oklahoma Medical School (United States)

Published in SPIE Proceedings Vol. 2387:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II
Robert R. Alfano, Editor(s)

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