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Proceedings Paper

Hyphenated GC-FTIR and GC-MS techniques applied in the analysis of bioactive compounds
Author(s): Steluta Gosav; Nicoleta Paduraru; Mirela Praisler
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Paper Abstract

The drugs of abuse, which affect human nature and cause numerous crimes, have become a serious problem throughout the world. There are hundreds of amphetamine analogues on the black market. They consist of various alterations of the basic amphetamine molecular structure, which are yet not yet included in the lists of forbidden compounds although they retain or slightly modify the hallucinogenic effects of their parent compound. It is their important variety that makes their identification quite a challenge. A number of analytical procedures for the identification of amphetamines and their analogues have recently been reported. We are presenting the profile of the main hallucinogenic amphetamines obtained with the hyphenated techniques that are recommended for the identification of illicit amphetamines, i. e. gas chromatography combined with mass spectrometry (GC-MS) and gas chromatography coupled with Fourier transform infrared spectrometry (GC-FTIR). The infrared spectra of the analyzed hallucinogenic amphetamines present some absorption bands (1490 cm-1, 1440 cm-1, 1245 cm-1, 1050 cm-1 and 940 cm-1) that are very stable as position and shape, while their intensity depends of the side-chain substitution. The specific ionic fragment of the studied hallucinogenic compounds is the 3,4-methylenedioxybenzyl cation (m/e = 135) which has a small relative abundance (lesser than 20%). The complementarity of the above mentioned techniques for the identification of hallucinogenic compounds is discussed.

Paper Details

Date Published: 22 August 2014
PDF: 9 pages
Proc. SPIE 9286, Second International Conference on Applications of Optics and Photonics, 92862D (22 August 2014); doi: 10.1117/12.2063898
Show Author Affiliations
Steluta Gosav, Dunarea de Jos Univ. (Romania)
Nicoleta Paduraru, Dunarea de Jos Univ. (Romania)
Mirela Praisler, Dunarea de Jos Univ. (Romania)

Published in SPIE Proceedings Vol. 9286:
Second International Conference on Applications of Optics and Photonics
Manuel Filipe P. C. Martins Costa; Rogério Nunes Nogueira, Editor(s)

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