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Proceedings Paper

Zepto-mole detection in microfluidics by novel nonlinear multi-photon laser wave-mixing spectroscopy for biomedical and environmental applications
Author(s): Marcel Hetu; Manna Iwabuchi; Eric Maxwell; Haoli Wu; Sashary Ramos; William G. Tong
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Paper Abstract

Laser wave-mixing detectors for microfluidics are presented as compact systems for parts-per-quadrillion-level detection of biomedical and environmental samples. Wave mixing offers unique advantages including absorption-based detection of micrometer-thin samples, generation of coherent laser-like signal beams, and sensitive detection of both fluorescing and non-fluorescing samples. Biomarkers could be detected in their native forms without labels, or if labels are desired, one could use both fluorophores and chromophores as labels. By coupling low-power (mW) solid-state lasers and microfluidics and microarrays, one can design compact optical systems that can be battery powered and used in the field for real-time fingerprinting of chemicals.

Paper Details

Date Published: 12 September 2014
PDF: 7 pages
Proc. SPIE 9193, Novel Optical Systems Design and Optimization XVII, 91930T (12 September 2014); doi: 10.1117/12.2062373
Show Author Affiliations
Marcel Hetu, San Diego State Univ. (United States)
Manna Iwabuchi, San Diego State Univ. (United States)
Eric Maxwell, San Diego State Univ. (United States)
Haoli Wu, San Diego State Univ. (United States)
Sashary Ramos, San Diego State Univ. (United States)
William G. Tong, San Diego State Univ. (United States)

Published in SPIE Proceedings Vol. 9193:
Novel Optical Systems Design and Optimization XVII
G. Groot Gregory; Arthur J. Davis, Editor(s)

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