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Proceedings Paper

Carotid plaque characterization using CT and MRI scans for synergistic image analysis
Author(s): Matthew Getzin; Yiqin Xu; Arhant Rao; Saaussan Madi; Ali Bahadur; Michelle R. Lennartz; Ge Wang
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Paper Abstract

Noninvasive determination of plaque vulnerability has been a holy grail of medical imaging. Despite advances in tomographic technologies , there is currently no effective way to identify vulnerable atherosclerotic plaques with high sensitivity and specificity. Computed tomography (CT) and magnetic resonance imaging (MRI) are widely used, but neither provides sufficient information of plaque properties. Thus, we are motivated to combine CT and MRI imaging to determine if the composite information can better reflect the histological determination of plaque vulnerability. Two human endarterectomy specimens (1 symptomatic carotid and 1 stable femoral) were imaged using Scanco Medical Viva CT40 and Bruker Pharmascan 16cm 7T Horizontal MRI / MRS systems. μCT scans were done at 55 kVp and tube current of 70 mA. Samples underwent RARE-VTR and MSME pulse sequences to measure T1, T2 values, and proton density. The specimens were processed for histology and scored for vulnerability using the American Heart Association criteria. Single modality-based analyses were performed through segmentation of key imaging biomarkers (i.e. calcification and lumen), image registration, measurement of fibrous capsule, and multi-component T1 and T2 decay modeling. Feature differences were analyzed between the unstable and stable controls, symptomatic carotid and femoral plaque, respectively. By building on the techniques used in this study, synergistic CT+MRI analysis may provide a promising solution for plaque characterization in vivo.

Paper Details

Date Published: 12 September 2014
PDF: 12 pages
Proc. SPIE 9212, Developments in X-Ray Tomography IX, 92121B (12 September 2014); doi: 10.1117/12.2062144
Show Author Affiliations
Matthew Getzin, Rensselaer Polytechnic Institute (United States)
Yiqin Xu, Albany Medical College (United States)
Arhant Rao, Albany Medical College (United States)
Saaussan Madi, Bruker Biospin Corp. (United States)
Ali Bahadur, Bruker Biospin Corp. (United States)
Michelle R. Lennartz, Albany Medical College (United States)
Ge Wang, Rensselaer Polytechnic Institute (United States)

Published in SPIE Proceedings Vol. 9212:
Developments in X-Ray Tomography IX
Stuart R. Stock, Editor(s)

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