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Proceedings Paper

Optical tweezers for free-solution label-free single bio-molecule studies
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Paper Abstract

Nanoaperture based trapping has developed as a significant tool among the various optical tweezer systems for trapping of very small particles down to the single nanometer range. The double nanohole aperture based trap provides a method for efficient, highly-sensitive, label-free, low-cost, free-solution single molecule trapping and detection. We use the double nanohole tweezer to understand biomolecular phenomena like protein unfolding, binding, structural conformation of DNA, protein-DNA interactions, and protein small molecule interactions.

Paper Details

Date Published: 16 September 2014
PDF: 5 pages
Proc. SPIE 9164, Optical Trapping and Optical Micromanipulation XI, 916418 (16 September 2014); doi: 10.1117/12.2062051
Show Author Affiliations
Abhay Kotnala, Univ. of Victoria (Canada)
Ahmed A. Al-Balushi, Univ. of Victoria (Canada)
Reuven Gordon, Univ. of Victoria (Canada)

Published in SPIE Proceedings Vol. 9164:
Optical Trapping and Optical Micromanipulation XI
Kishan Dholakia; Gabriel C. Spalding, Editor(s)

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