
Proceedings Paper
The whispering gallery mode biosensor: label-free detection from virus to single proteinFormat | Member Price | Non-Member Price |
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Paper Abstract
The whispering gallery mode (WGM) biosensor is a micro-optical platform capable of sensitive label-free detection of
biological particles. Described by the reactive sensing principle (RSP), this analytic formulation quantifies the response
of the system to the adsorption of bioparticles. Guided by the RSP, the WGM biosensor enabling from detection of virus
(e.g., Human Papillomavirus, HPV) to the ultimate goal of single protein detection. The latter was derived from insights
into the RSP, which resulted in the development of a hybrid plasmonic WGM biosensor, which has recently
demonstrated detection of individual protein cancer markers. Enhancements from bound gold nanoparticles provide the
sensitivity to detect single protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of
proteins as small as 5 kDa.
Paper Details
Date Published: 28 August 2014
PDF: 8 pages
Proc. SPIE 9166, Biosensing and Nanomedicine VII, 91660O (28 August 2014); doi: 10.1117/12.2061477
Published in SPIE Proceedings Vol. 9166:
Biosensing and Nanomedicine VII
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)
PDF: 8 pages
Proc. SPIE 9166, Biosensing and Nanomedicine VII, 91660O (28 August 2014); doi: 10.1117/12.2061477
Show Author Affiliations
S. Holler, Fordham Univ. (United States)
V. R. Dantham, Polytechnic Institute of New York Univ. (United States)
D. Keng, Polytechnic Institute of New York Univ. (United States)
V. Kolchenko, New York City College of Technology (United States)
V. R. Dantham, Polytechnic Institute of New York Univ. (United States)
D. Keng, Polytechnic Institute of New York Univ. (United States)
V. Kolchenko, New York City College of Technology (United States)
S. Arnold, Polytechnic Institute of New York Univ. (United States)
Brigid Mulroe, Fordham Univ. (United States)
M. Paspaley-Grbavac, Fordham Univ. (United States)
Brigid Mulroe, Fordham Univ. (United States)
M. Paspaley-Grbavac, Fordham Univ. (United States)
Published in SPIE Proceedings Vol. 9166:
Biosensing and Nanomedicine VII
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)
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