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Proceedings Paper

Atmospheric pressure operation of a repetitive KrF laser-plasma x-ray source at hv = 1.1 keV
Author(s): I. C. Edmond Turcu; Fergus O'Neill; Gregory J. Tallents; T. Hannon; Dimitri Batani; Antonio Giulietti; C. W. Wharton; R. A. Meldrum
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Paper Abstract

A repetitively pulsed (5Hz) KrF laser-based X-ray source producing photons at i-ru 1.1 keV (copper, L-shell) from a copper coated rotating target has been used to study soft X-ray induced DNA damage effects in Chinese hamster cells. The source was computer controlled for accurate delivery to the biological material of pre-set doses. DNA damage was induced by exposures lasting 7s for V79 cells and 40s for AA8 cells. To minimise the debris from the laser-plasma source and for convenient handling of biological specimens, the target chamber contained helium at 1 atmosphere with a slow flow. The X-ray yield of the source decreased by only at most 10-20% compared to vacuum operation and a further 16% of X-rays were absorbed in helium between target and the biological material placed outside the target chamber behind a beryllium filter. The measured spectral and spatial distribution of the copper X-ray emission was found to be largely independent of the ambient helium pressure. The time resolved X-ray signal lasted for only 3 ns starting at the beginning of the 2lns laser pulse and its shape was independent of helium pressure in the target chamber.

Paper Details

Date Published: 1 August 1990
PDF: 11 pages
Proc. SPIE 1278, Excimer Lasers and Applications II, (1 August 1990);
Show Author Affiliations
I. C. Edmond Turcu, Rutherford Appleton Lab. (United States)
Fergus O'Neill, Rutherford Appleton Lab. (Ireland)
Gregory J. Tallents, Rutherford Appleton Lab. (United Kingdom)
T. Hannon, Rutherford Appleton Lab. (United Kingdom)
Dimitri Batani, Istituto di Fisica Atomica e M (Italy)
Antonio Giulietti, Istituto di Fisica Atomica e Molecolare (Italy)
C. W. Wharton, Univ. of Birmingham (United Kingdom)
R. A. Meldrum, Univ. of Birmingham (United Kingdom)

Published in SPIE Proceedings Vol. 1278:
Excimer Lasers and Applications II
Tommaso Letardi, Editor(s)

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