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Proceedings Paper

Tumors in murine brains studied by grating-based phase contrast microtomography
Author(s): Georg Schulz; Marco Dominietto; Zsofia Kovacs; Rüdiger Schmitz; Simone E. Hieber; Peter Thalmann; Felix Beckmann; Bert Müller
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Paper Abstract

Angiogenesis, i.e. the formation of vessels, is one of the key processes during tumor development. The newly formed vessels transport oxygen and nutrients from the healthy tissue to the tumor and gives tumor cells the possibility to replicate. The principle of anti-angiogenic therapy is to block angiogenic process in order to stop tumor growth. The aim of the present study is the investigation of murine glioma vascular architecture at early (7 days), intermediate (10 and 15 days) and late (23 days) stage of growth by means of grating-based phase contrast microtomography. We demonstrate that this technique yields premium contrast between healthy and cancerous parts of murine brain tissues.

Paper Details

Date Published: 12 September 2014
PDF: 12 pages
Proc. SPIE 9212, Developments in X-Ray Tomography IX, 92120Q (12 September 2014); doi: 10.1117/12.2060544
Show Author Affiliations
Georg Schulz, Univ. Hospital Basel (Switzerland)
Marco Dominietto, Univ. Hospital Basel (Switzerland)
ETH Zürich (Switzerland)
Zsofia Kovacs, Univ. Children's Hospital Zürich (Switzerland)
Rüdiger Schmitz, Univ. Hospital Basel (Switzerland)
Simone E. Hieber, Univ. Hospital Basel (Switzerland)
Peter Thalmann, Univ. Hospital Basel (Switzerland)
Felix Beckmann, Helmholtz-Zentrum Geesthacht (Germany)
Bert Müller, Univ. Hospital Basel (Switzerland)

Published in SPIE Proceedings Vol. 9212:
Developments in X-Ray Tomography IX
Stuart R. Stock, Editor(s)

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