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Proceedings Paper

Polarimetric fiber grating biosensor for in-situ high-sensitive intracellular density measurement
Author(s): Tuan Guo; Fu Liu; Yu Liu; Nan-Kuang Chen; Bai-Ou Guan; Jacques Albert
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Paper Abstract

High sensitivity biological sample measurements have been achieved by using a 12o tilted fiber Bragg grating (TFBG). Human acute leukemia cells with different intracellular densities and refractive index (RI) ranging from 1.3342 to 1.3344 were clearly discriminated in-situ by using the differential transmission spectrum between two orthogonal polarizations for the last guided mode resonance before “cut-off”, with an amplitude variation sensitivity of 1.8×104 dB/RIU and a limit of detection of 2×10-5 RIU. The technique is inherently temperature-insensitive.

Paper Details

Date Published: 2 June 2014
PDF: 4 pages
Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 915746 (2 June 2014); doi: 10.1117/12.2058465
Show Author Affiliations
Tuan Guo, Jinan Univ. (China)
Fu Liu, Jinan Univ. (China)
Yu Liu, Jinan Univ. (China)
Nan-Kuang Chen, National United Univ. (Taiwan)
Bai-Ou Guan, Jinan Univ. (China)
Jacques Albert, Carleton Univ. (Canada)

Published in SPIE Proceedings Vol. 9157:
23rd International Conference on Optical Fibre Sensors
José M. López-Higuera; Julian D. C. Jones; Manuel López-Amo; José Luis Santos, Editor(s)

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