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Proceedings Paper

Analysis of temporal dynamics in imagery during acute limb ischemia and reperfusion
Author(s): John M. Irvine; John Regan; Tammy A. Spain; Joseph D. Caruso; Maricela Rodriquez; Rajiv Luthra; Jonathon Forsberg; Nicole J. Crane; Eric Elster
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Paper Abstract

Ischemia and reperfusion injuries present major challenges for both military and civilian medicine. Improved methods for assessing the effects and predicting outcome could guide treatment decisions. Specific issues related to ischemia and reperfusion injury can include complications arising from tourniquet use, such as microvascular leakage in the limb, loss of muscle strength and systemic failures leading to hypotension and cardiac failure. Better methods for assessing the viability of limbs/tissues during ischemia and reducing complications arising from reperfusion are critical to improving clinical outcomes for at-risk patients. The purpose of this research is to develop and assess possible prediction models of outcome for acute limb ischemia using a pre-clinical model. Our model relies only on non-invasive imaging data acquired from an animal study. Outcome is measured by pathology and functional scores. We explore color, texture, and temporal features derived from both color and thermal motion imagery acquired during ischemia and reperfusion. The imagery features form the explanatory variables in a model for predicting outcome. Comparing model performance to outcome prediction based on direct observation of blood chemistry, blood gas, urinalysis, and physiological measurements provides a reference standard. Initial results show excellent performance for the imagery-base model, compared to predictions based direct measurements. This paper will present the models and supporting analysis, followed by recommendations for future investigations.

Paper Details

Date Published: 11 March 2014
PDF: 9 pages
Proc. SPIE 9037, Medical Imaging 2014: Image Perception, Observer Performance, and Technology Assessment, 90371F (11 March 2014); doi: 10.1117/12.2043958
Show Author Affiliations
John M. Irvine, Draper Lab. (United States)
John Regan, Draper Lab. (United States)
Tammy A. Spain, Draper Lab. (United States)
Joseph D. Caruso, Naval Medical Research Ctr. (United States)
Maricela Rodriquez, Naval Medical Research Ctr. (United States)
Rajiv Luthra, Naval Medical Research Ctr. (United States)
Jonathon Forsberg, Naval Medical Research Ctr. (United States)
Nicole J. Crane, Naval Medical Research Ctr. (United States)
Eric Elster, Naval Medical Research Ctr. (United States)

Published in SPIE Proceedings Vol. 9037:
Medical Imaging 2014: Image Perception, Observer Performance, and Technology Assessment
Claudia R. Mello-Thoms; Matthew A. Kupinski, Editor(s)

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