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Proceedings Paper

In-line X-ray phase-contrast lung imaging In situ with a benchtop system
Author(s): A. B. Garson; E. W. Izaguirre; S. G. Price; H. Guan; S. K. Vasireddi; M. A. Anastasio
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Paper Abstract

X-ray phase-contrast (XPC) imaging methods are well-suited for lung imaging applications due to the weakly absorbing nature of lung tissue and the strong refractive effects associated with tissue-air interfaces. Until recently, XPC lung imaging had only been accomplished at synchrotron facilities. In this work, we investigate the manifestation of speckle in propagation-based XPC images of mouse lungs acquired in situ by use of a benchtop imager. The key contributions of the work are: a) the demonstration that lung speckle can be observed by use of a benchtop XPC imaging system employing a polychromatic tube-source; and b) a systematic experimental investigation of how the texture of the speckle pattern depends on the parameters of the imaging system. Our analyses consists of image texture characterization based on the statistical properties of pixel intensity distributions. Results show how image texture measures of lung regions are strongly dependent on imaging system parameters associated with XPC sensitivity.

Paper Details

Date Published: 19 March 2014
PDF: 7 pages
Proc. SPIE 9033, Medical Imaging 2014: Physics of Medical Imaging, 90330A (19 March 2014); doi: 10.1117/12.2043936
Show Author Affiliations
A. B. Garson, Washington Univ. in St. Louis (United States)
E. W. Izaguirre, Scott and White Healthcare (United States)
S. G. Price, Washington Univ. School of Medicine, St. Louis (United States)
H. Guan, Washington Univ. in St. Louis (United States)
S. K. Vasireddi, Washington Univ. in St. Louis (United States)
M. A. Anastasio, Washington Univ. in St. Louis (United States)

Published in SPIE Proceedings Vol. 9033:
Medical Imaging 2014: Physics of Medical Imaging
Bruce R. Whiting; Christoph Hoeschen, Editor(s)

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