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Proceedings Paper

Mapping of ApoE4 related white matter damage using diffusion MRI
Author(s): Sinchai Tsao; Niharika Gajawelli; Darryl H. Hwang; Stephen Kriger; Meng Law; Helena Chui; Michael Weiner; Natasha Lepore
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Paper Abstract

ApoliopoproteinE Ɛ4 (ApoE-Ɛ4) polymorphism is the most well known genetic risk factor for developing Alzheimers Disease. The exact mechanism through which ApoE 4 increases AD risk is not fully known, but may be related to decreased clearance and increased oligomerization of Aβ. By making measurements of white matter integrity via diffusion MR and correlating the metrics in a voxel-based statistical analysis with ApoE-Ɛ4 genotype (whilst controlling for vascular risk factor, gender, cognitive status and age) we are able to identify changes in white matter associated with carrying an ApoE Ɛ4 allele. We found potentially significant regions (Puncorrected < 0:05) near the hippocampus and the posterior cingulum that were independent of voxels that correlated with age or clinical dementia rating (CDR) status suggesting that ApoE may affect cognitive decline via a pathway in dependent of normal aging and acute insults that can be measured by CDR and Framingham Coronary Risk Score (FCRS).

Paper Details

Date Published: 9 April 2014
PDF: 5 pages
Proc. SPIE 9039, Medical Imaging 2014: PACS and Imaging Informatics: Next Generation and Innovations, 90390H (9 April 2014); doi: 10.1117/12.2043925
Show Author Affiliations
Sinchai Tsao, Univ. of Washington (United States)
Niharika Gajawelli, The Univ. of Southern California (United States)
Children's Hospital Los Angeles (United States)
Darryl H. Hwang, The Univ. of Southern California (United States)
Stephen Kriger, San Francisco V. A. Medical Ctr. (United States)
Meng Law, The Univ. of Southern California (United States)
Helena Chui, The Univ. of Southern California (United States)
Michael Weiner, San Francisco V. A. Medical Ctr. (United States)
Natasha Lepore, The Univ. of Southern California (United States)
Children's Hospital Los Angeles (United States)


Published in SPIE Proceedings Vol. 9039:
Medical Imaging 2014: PACS and Imaging Informatics: Next Generation and Innovations
Maria Y. Law; Tessa S. Cook, Editor(s)

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