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Proceedings Paper

Accelerated self-gated UTE MRI of the murine heart
Author(s): Abdallah G. Motaal; Nils Noorman; Wolter L. De Graaf; Luc J. Florack; Klaas Nicolay; Gustav J. Strijkers
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Paper Abstract

We introduce a new protocol to obtain radial Ultra-Short TE (UTE) MRI Cine of the beating mouse heart within reasonable measurement time. The method is based on a self-gated UTE with golden angle radial acquisition and compressed sensing reconstruction. The stochastic nature of the retrospective triggering acquisition scheme produces an under-sampled and random kt-space filling that allows for compressed sensing reconstruction, hence reducing scan time. As a standard, an intragate multislice FLASH sequence with an acquisition time of 4.5 min per slice was used to produce standard Cine movies of 4 mice hearts with 15 frames per cardiac cycle. The proposed self-gated sequence is used to produce Cine movies with short echo time. The total scan time was 11 min per slice. 6 slices were planned to cover the heart from the base to the apex. 2X, 4X and 6X under-sampled k-spaces cine movies were produced from 2, 1 and 0.7 min data acquisitions for each slice. The accelerated cine movies of the mouse hearts were successfully reconstructed with a compressed sensing algorithm. Compared to the FLASH cine images, the UTE images showed much less flow artifacts due to the short echo time. Besides, the accelerated movies had high image quality and the undersampling artifacts were effectively removed. Left ventricular functional parameters derived from the standard and the accelerated cine movies were nearly identical.

Paper Details

Date Published: 13 March 2014
PDF: 8 pages
Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 903803 (13 March 2014); doi: 10.1117/12.2043806
Show Author Affiliations
Abdallah G. Motaal, Eindhoven Univ. of Technology (Netherlands)
Nils Noorman, Eindhoven Univ. of Technology (Netherlands)
Wolter L. De Graaf, Eindhoven Univ. of Technology (Netherlands)
Luc J. Florack, Eindhoven Univ. of Technology (Netherlands)
Klaas Nicolay, Eindhoven Univ. of Technology (Netherlands)
Gustav J. Strijkers, Eindhoven Univ. of Technology (Netherlands)

Published in SPIE Proceedings Vol. 9038:
Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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