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Proceedings Paper

Determination of minor and trace elements in kidney stones by x-ray fluorescence analysis
Author(s): Anjali Srivastava; Brianne J. Heisinger; Vaibhav Sinha; Hyong-Koo Lee; Xin Liu; Mingliang Qu; Xinhui Duan; Shuai Leng; Cynthia H. McCollough
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Paper Abstract

The determination of accurate material composition of a kidney stone is crucial for understanding the formation of the kidney stone as well as for preventive therapeutic strategies. Radiations probing instrumental activation analysis techniques are excellent tools for identification of involved materials present in the kidney stone. In particular, x-ray fluorescence (XRF) can be very useful for the determination of minor and trace materials in the kidney stone. The X-ray fluorescence measurements were performed at the Radiation Measurements and Spectroscopy Laboratory (RMSL) of department of nuclear engineering of Missouri University of Science and Technology and different kidney stones were acquired from the Mayo Clinic, Rochester, Minnesota. Presently, experimental studies in conjunction with analytical techniques were used to determine the exact composition of the kidney stone. A new type of experimental set-up was developed and utilized for XRF analysis of the kidney stone. The correlation of applied radiation source intensity, emission of X-ray spectrum from involving elements and absorption coefficient characteristics were analyzed. To verify the experimental results with analytical calculation, several sets of kidney stones were analyzed using XRF technique. The elements which were identified from this techniques are Silver (Ag), Arsenic (As), Bromine (Br), Chromium (Cr), Copper (Cu), Gallium (Ga), Germanium (Ge), Molybdenum (Mo), Niobium (Nb), Rubidium (Rb), Selenium (Se), Strontium (Sr), Yttrium (Y), Zirconium (Zr). This paper presents a new approach for exact detection of accurate material composition of kidney stone materials using XRF instrumental activation analysis technique.

Paper Details

Date Published: 19 March 2014
PDF: 8 pages
Proc. SPIE 9033, Medical Imaging 2014: Physics of Medical Imaging, 90335R (19 March 2014); doi: 10.1117/12.2043733
Show Author Affiliations
Anjali Srivastava, Missouri Univ. of Science and Technology (United States)
Brianne J. Heisinger, Missouri Univ. of Science and Technology (United States)
Vaibhav Sinha, Missouri Univ. of Science and Technology (United States)
Hyong-Koo Lee, Missouri Univ. of Science and Technology (United States)
Xin Liu, Missouri Univ. of Science and Technology (United States)
Mingliang Qu, Mayo Clinic (United States)
Xinhui Duan, Mayo Clinic (United States)
Shuai Leng, Mayo Clinic (United States)
Cynthia H. McCollough, Mayo Clinic (United States)

Published in SPIE Proceedings Vol. 9033:
Medical Imaging 2014: Physics of Medical Imaging
Bruce R. Whiting; Christoph Hoeschen, Editor(s)

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