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Proceedings Paper

Robust optic nerve segmentation on clinically acquired CT
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Paper Abstract

The optic nerve is a sensitive central nervous system structure, which plays a critical role in many devastating pathological conditions. Several methods have been proposed in recent years to segment the optic nerve automatically, but progress toward full automation has been limited. Multi-atlas methods have been successful for brain segmentation, but their application to smaller anatomies remains relatively unexplored. Herein we evaluate a framework for robust and fully automated segmentation of the optic nerves, eye globes and muscles. We employ a robust registration procedure for accurate registrations, variable voxel resolution and image fieldof- view. We demonstrate the efficacy of an optimal combination of SyN registration and a recently proposed label fusion algorithm (Non-local Spatial STAPLE) that accounts for small-scale errors in registration correspondence. On a dataset containing 30 highly varying computed tomography (CT) images of the human brain, the optimal registration and label fusion pipeline resulted in a median Dice similarity coefficient of 0.77, symmetric mean surface distance error of 0.55 mm, symmetric Hausdorff distance error of 3.33 mm for the optic nerves. Simultaneously, we demonstrate the robustness of the optimal algorithm by segmenting the optic nerve structure in 316 CT scans obtained from 182 subjects from a thyroid eye disease (TED) patient population.

Paper Details

Date Published: 21 March 2014
PDF: 10 pages
Proc. SPIE 9034, Medical Imaging 2014: Image Processing, 90341G (21 March 2014); doi: 10.1117/12.2043715
Show Author Affiliations
Swetasudha Panda, Vanderbilt Univ. (United States)
Andrew J. Asman, Vanderbilt Univ. (United States)
Michael P. DeLisi, Vanderbilt Univ. (United States)
Louise A. Mawn, Vanderbilt Univ. (United States)
Robert L. Galloway, Vanderbilt Univ. (United States)
Bennett A. Landman, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 9034:
Medical Imaging 2014: Image Processing
Sebastien Ourselin; Martin A. Styner, Editor(s)

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