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Proceedings Paper

Toward 3D-guided prostate biopsy target optimization: an estimation of tumor sampling probabilities
Author(s): Peter R. Martin; Derek W. Cool; Cesare Romagnoli; Aaron Fenster; Aaron D. Ward
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Paper Abstract

Magnetic resonance imaging (MRI)-targeted, 3D transrectal ultrasound (TRUS)-guided “fusion” prostate biopsy aims to reduce the ~23% false negative rate of clinical 2D TRUS-guided sextant biopsy. Although it has been reported to double the positive yield, MRI-targeted biopsy still yields false negatives. Therefore, we propose optimization of biopsy targeting to meet the clinician’s desired tumor sampling probability, optimizing needle targets within each tumor and accounting for uncertainties due to guidance system errors, image registration errors, and irregular tumor shapes. We obtained multiparametric MRI and 3D TRUS images from 49 patients. A radiologist and radiology resident contoured 81 suspicious regions, yielding 3D surfaces that were registered to 3D TRUS. We estimated the probability, P, of obtaining a tumor sample with a single biopsy. Given an RMS needle delivery error of 3.5 mm for a contemporary fusion biopsy system, P ≥ 95% for 21 out of 81 tumors when the point of optimal sampling probability was targeted. Therefore, more than one biopsy core must be taken from 74% of the tumors to achieve P ≥ 95% for a biopsy system with an error of 3.5 mm. Our experiments indicated that the effect of error along the needle axis on the percentage of core involvement (and thus the measured tumor burden) was mitigated by the 18 mm core length.

Paper Details

Date Published: 12 March 2014
PDF: 6 pages
Proc. SPIE 9036, Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling, 90361C (12 March 2014); doi: 10.1117/12.2043543
Show Author Affiliations
Peter R. Martin, Univ. of Western Ontario (Canada)
Derek W. Cool, Univ. of Western Ontario (Canada)
Robarts Research Institute (Canada)
Cesare Romagnoli, Univ. of Western Ontario (Canada)
Aaron Fenster, Univ. of Western Ontario (Canada)
Robarts Research Institute (Canada)
Aaron D. Ward, Univ. of Western Ontario (Canada)

Published in SPIE Proceedings Vol. 9036:
Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling
Ziv R. Yaniv; David R. Holmes III, Editor(s)

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