Share Email Print

Proceedings Paper

A dual spherical model for multi-shell diffusion imaging
Author(s): Y. Rathi; O. Michailovich; K. Setsompop; C.-F. Westin
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Multi-shell diffusion imaging (MSDI) allows to characterize the subtle tissue properties of neurons along with providing valuable information about the ensemble average diffusion propagator. Several methods, both para- metric and non-parametric, have been proposed to analyze MSDI data. In this work, we propose a hybrid model, which is non-parametric in the angular domain but parametric in the radial domain. This has the advantage of allowing arbitrary number of fiber orientations in the angular domain, yet requiring as little as two b-value shells in the radial (q-space) domain. Thus, an extensive sampling of the q-space is not required to compute the diffusion propagator. This model, which we term as the dual-spherical" model, requires estimation of two functions on the sphere to completely (and continuously) model the entire q-space diffusion signal. Specifically, we formulate the cost function so that the diffusion signal is guaranteed to monotonically decrease with b-value for user-defined range of b-values. This is in contrast to other methods, which do not enforce such a constraint, resulting in in-accurate modeling of the diffusion signal (where the signal values could potentially increase with b-value). We also show the relation of our proposed method with that of diffusional kurtosis imaging and how our model extends the kurtosis model. We use the standard spherical harmonics to estimate these functions on the sphere and show its efficacy using synthetic and in-vivo experiments. In particular, on synthetic data, we computed the normalized mean squared error and the average angular error in the estimated orientation distribution function (ODF) and show that the proposed technique works better than the existing work which only uses a parametric model for estimating the radial decay of the diffusion signal with b-value.

Paper Details

Date Published: 21 March 2014
PDF: 6 pages
Proc. SPIE 9034, Medical Imaging 2014: Image Processing, 90340Q (21 March 2014); doi: 10.1117/12.2043493
Show Author Affiliations
Y. Rathi, Harvard Medical School (United States)
O. Michailovich, Univ. of Waterloo (Canada)
K. Setsompop, Harvard Medical School (United States)
C.-F. Westin, Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 9034:
Medical Imaging 2014: Image Processing
Sebastien Ourselin; Martin A. Styner, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?