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Proceedings Paper

Prostate tissue decomposition via DECT using the model based iterative image reconstruction algorithm DIRA
Author(s): Alexandr Malusek; Maria Magnusson; Michael Sandborg; Robin Westin; Gudrun Alm Carlsson
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Paper Abstract

Better knowledge of elemental composition of patient tissues may improve the accuracy of absorbed dose delivery in brachytherapy. Deficiencies of water-based protocols have been recognized and work is ongoing to implement patient-specific radiation treatment protocols. A model based iterative image reconstruction algorithm DIRA has been developed by the authors to automatically decompose patient tissues to two or three base components via dual-energy computed tomography. Performance of an updated version of DIRA was evaluated for the determination of prostate calcification. A computer simulation using an anthropomorphic phantom showed that the mass fraction of calcium in the prostate tissue was determined with accuracy better than 9%. The calculated mass fraction was little affected by the choice of the material triplet for the surrounding soft tissue. Relative differences between true and approximated values of linear attenuation coefficient and mass energy absorption coefficient for the prostate tissue were less than 6% for photon energies from 1 keV to 2 MeV. The results indicate that DIRA has the potential to improve the accuracy of dose delivery in brachytherapy despite the fact that base material triplets only approximate surrounding soft tissues.

Paper Details

Date Published: 19 March 2014
PDF: 9 pages
Proc. SPIE 9033, Medical Imaging 2014: Physics of Medical Imaging, 90333H (19 March 2014); doi: 10.1117/12.2043445
Show Author Affiliations
Alexandr Malusek, Linköping Univ. (Sweden)
Maria Magnusson, Linköping Univ. (Sweden)
Michael Sandborg, Linköping Univ. (Sweden)
Robin Westin, Linköping Univ. (Sweden)
Gudrun Alm Carlsson, Linköping Univ. (Sweden)


Published in SPIE Proceedings Vol. 9033:
Medical Imaging 2014: Physics of Medical Imaging
Bruce R. Whiting; Christoph Hoeschen, Editor(s)

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