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Proceedings Paper

Shape-constrained multi-atlas segmentation of spleen in CT
Author(s): Zhoubing Xu; Bo Li; Swetasudha Panda; Andrew J. Asman; Kristen L. Merkle; Peter L. Shanahan; Richard G. Abramson; Bennett A. Landman
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Paper Abstract

Spleen segmentation on clinically acquired CT data is a challenging problem given the complicity and variability of abdominal anatomy. Multi-atlas segmentation is a potential method for robust estimation of spleen segmentations, but can be negatively impacted by registration errors. Although labeled atlases explicitly capture information related to feasible organ shapes, multi-atlas methods have largely used this information implicitly through registration. We propose to integrate a level set shape model into the traditional label fusion framework to create a shape-constrained multi-atlas segmentation framework. Briefly, we (1) adapt two alternative atlas-to-target registrations to obtain the loose bounds on the inner and outer boundaries of the spleen shape, (2) project the fusion estimate to registered shape models, and (3) convert the projected shape into shape priors. With the constraint of the shape prior, our proposed method offers a statistically significant improvement in spleen labeling accuracy with an increase in DSC by 0.06, a decrease in symmetric mean surface distance by 4.01 mm, and a decrease in symmetric Hausdorff surface distance by 23.21 mm when compared to a locally weighted vote (LWV) method.

Paper Details

Date Published: 21 March 2014
PDF: 6 pages
Proc. SPIE 9034, Medical Imaging 2014: Image Processing, 903446 (21 March 2014); doi: 10.1117/12.2043079
Show Author Affiliations
Zhoubing Xu, Vanderbilt Univ. (United States)
Bo Li, Vanderbilt Univ. (United States)
Swetasudha Panda, Vanderbilt Univ. (United States)
Andrew J. Asman, Vanderbilt Univ. (United States)
Kristen L. Merkle, Vanderbilt Univ. (United States)
Peter L. Shanahan, Vanderbilt Univ. (United States)
Richard G. Abramson, Vanderbilt Univ. (United States)
Bennett A. Landman, Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 9034:
Medical Imaging 2014: Image Processing
Sebastien Ourselin; Martin A. Styner, Editor(s)

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