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Proceedings Paper

In vivo elemental analysis by counting neutron-induced gamma rays for medical and biological applications
Author(s): Joseph J. Kehayias; Ruimei Ma; Hong Zhuang; Robert Moore; Lisa Dowling
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Paper Abstract

Non-invasive in vivo elemental analysis is a technique used to assess human body composition which is indicative of nutritional status and health condition. The in vivo measurement of the body's major elements is used for a variety of medical studies requiring the determination of the body's compartments (protein, fat, water, bone). Whole body gamma-ray counters, consisting of Nal(Tl) crystal detectors in a shielded room, are used for measuring in vivo the body's Ca, Cl, Na and P by delayed neutron activation analysis. Thermal neutrons from a moderated 238Pu-Be source are used for the measurement of total body nitrogen (and thus protein) and chlorine at low radiation exposure (0.80 mSv). The resulting high energy prompt gamma-rays from nitrogen (10.83 MeV) and chlorine (6.11 MeV) are detected simultaneously with the irradiation. Body fat (the main energy store) and fat distribution (which relates to risk for cardiovascular disease) are measured by detecting C and O in vivo through fast neutron inelastic scattering. A small sealed D-T neutron generator is used for the pulsed (4 - 8 KHz) production of fast neutrons. Carbon and oxygen are detected by counting the 4.44 and 6.13 MeV gamma-rays resulting from the inelastic scattering of the fast neutrons from the 12C and 16O nuclei, respectively. One use of this method is the systematic study of the mechanisms driving the age-associated depletion of the metabolizing, oxygen-consuming cellular compartment of the body. The understanding of this catabolism may suggest ways to maintain lean tissue and thus to preserve quality of life for the very old.

Paper Details

Date Published: 3 March 1995
PDF: 5 pages
Proc. SPIE 2339, International Conference on Neutrons and Their Applications, (3 March 1995);
Show Author Affiliations
Joseph J. Kehayias, USDA Human Nutrition Research Ctr. (United States)
Ruimei Ma, Brookhaven National Lab. (United States)
Hong Zhuang, USDA Human Nutrition Research Ctr. (United States)
Robert Moore, Brookhaven National Lab. (United States)
Lisa Dowling, USDA Human Nutrition Research Ctr. (United States)

Published in SPIE Proceedings Vol. 2339:
International Conference on Neutrons and Their Applications
George Vourvopoulos; Themis Paradellis, Editor(s)

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