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Proceedings Paper

Toward in vivo diagnosis of skin cancer using multimode imaging dermoscopy: (I) clinical system development and validation
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Paper Abstract

We introduce the new clinical prototype of SkinSpect – a multimode dermoscope combining fluorescence, polarization and hyperspectral imaging. The system determines relative melanin and hemoglobin concentrations as well as oxygen saturation while effectively correcting for the melanin-hemoglobin crosstalk commonly observed in other spectral dermoscopy approaches. Optical specifications and performance of this new clinical and our previous research prototypes are compared. Light source programming and image polarization selection using LCVR are optimized to improve the accuracy of skin chromophore quantitation. Polarized attenuation spectra are computed and applied to a Beer-Lambert linear model to extract the relative contributions of chromophores at every pixel.

Paper Details

Date Published: 4 March 2014
PDF: 10 pages
Proc. SPIE 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, 89470I (4 March 2014); doi: 10.1117/12.2041818
Show Author Affiliations
Nicholas MacKinnon, Spectral Molecular Imaging Inc. (United States)
Fartash Vasefi, Spectral Molecular Imaging Inc. (United States)
Daniel L. Farkas, Spectral Molecular Imaging Inc. (United States)
The Univ. of Southern California (United States)

Published in SPIE Proceedings Vol. 8947:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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