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Proceedings Paper

Development of a spectrally resolved fluorescence tomography system using a NIR swept laser and a digital micromirror array based detection system
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Paper Abstract

We developed a spectrally-resolved fluorescence tomography (FT) system using a new source and detection unit. On the source side, we utilized a near-infrared (NIR) swept laser-based technology and on the detection side, we developed a digital micromirror device (DMD) based spectrally-resolved detection unit. We demonstrated the development of a NIR swept laser centered at 800 nm for FT, which covers the maximum absorption wavelength of a NIR fluorescence dye, indo-cyanine green (ICG) in plasma. Two different ICG samples whose absorption characteristics were slightly different were used to demonstrate the performance of the NIR swept laser-based FT system, and this FT system was able to show the difference of absorption between the ICG samples. In addition, we also developed a prototype spectrally-resolved detection unit based on the DMD. This detection system provided a spectral resolution of 15 nm and the possibility of simultaneous detection of multiple fluorescence spectra.

Paper Details

Date Published: 4 March 2014
PDF: 6 pages
Proc. SPIE 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, 89470Z (4 March 2014); doi: 10.1117/12.2041151
Show Author Affiliations
Jaedu Cho, Univ. of California, Irvine (United States)
Seung Woan Jeon, Pusan National Univ. (Korea, Republic of)
Jie Zheng, Univ. of California, Irvine (United States)
Chang-Seok Kim, Pusan National Univ. (Korea, Republic of)
Orhan Nalcioglu, Univ. of California, Irvine (United States)
Pusan National Univ. (Korea, Republic of)
Gultekin Gulsen, Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 8947:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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