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Proceedings Paper

10×10-pixel 606kS/s multi-point fluorescence correlation spectroscopy CMOS image sensor
Author(s): Keiichiro Kagawa; Taishi Takasawa; Zhang Bo; Min-Woong Seo; Kaita Imai; Jotaro Yamamoto; Masataka Kinjo; Susumu Terakawa; Keita Yasutomi; Shoji Kawahito
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Paper Abstract

To observe molecular transport in a living cell, a high-speed CMOS image sensor for multi-point fluorescence correlation spectroscopy is developed. To achieve low-noise and high-speed simultaneously, a prototype CMOS image sensor is designed based on a complete pixel-parallel architecture and multi-channel pipelined pixel readout. The prototype chip with 10×10 effective pixels is fabricated in 0.18-μm CMOS image sensor technology. The pixel pitch and the photosensitive area are 56μm and 10μm in diameter without a microlens, respectively. In the experiment, the total sampling rate of 606kS/s is achieved. The measured average random noise is 24.9LSB, which is equivalent to about 2.5 electrons in average.

Paper Details

Date Published: 4 March 2014
PDF: 7 pages
Proc. SPIE 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, 894713 (4 March 2014); doi: 10.1117/12.2041131
Show Author Affiliations
Keiichiro Kagawa, Shizuoka Univ. (Japan)
Taishi Takasawa, Shizuoka Univ. (Japan)
Zhang Bo, Shizuoka Univ. (Japan)
Min-Woong Seo, Shizuoka Univ. (Japan)
Kaita Imai, Shizuoka Univ. (Japan)
Jotaro Yamamoto, Hokkaido Univ. (Japan)
Masataka Kinjo, Hokkaido Univ. (Japan)
Susumu Terakawa, Hamamatsu Univ. School of Medicine (Japan)
Keita Yasutomi, Shizuoka Univ. (Japan)
Shoji Kawahito, Shizuoka Univ. (Japan)


Published in SPIE Proceedings Vol. 8947:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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