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Proceedings Paper

Image-guided plasma therapy of cutaneous wound
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Paper Abstract

The wound healing process involves the reparative phases of inflammation, proliferation, and remodeling. Interrupting any of these phases may result in chronically unhealed wounds, amputation, or even patient death. Despite the clinical significance in chronic wound management, no effective methods have been developed for quantitative image-guided treatment. We integrated a multimodal imaging system with a cold atmospheric plasma probe for image-guided treatment of chronic wound. Multimodal imaging system offers a non-invasive, painless, simultaneous and quantitative assessment of cutaneous wound healing. Cold atmospheric plasma accelerates the wound healing process through many mechanisms including decontamination, coagulation and stimulation of the wound healing. The therapeutic effect of cold atmospheric plasma is studied in vivo under the guidance of a multimodal imaging system. Cutaneous wounds are created on the dorsal skin of the nude mice. During the healing process, the sample wound is treated by cold atmospheric plasma at different controlled dosage, while the control wound is healed naturally. The multimodal imaging system integrating a multispectral imaging module and a laser speckle imaging module is used to collect the information of cutaneous tissue oxygenation (i.e. oxygen saturation, StO2) and blood perfusion simultaneously to assess and guide the plasma therapy. Our preliminary tests show that cold atmospheric plasma in combination with multimodal imaging guidance has the potential to facilitate the healing of chronic wounds.

Paper Details

Date Published: 27 February 2014
PDF: 7 pages
Proc. SPIE 8935, Advanced Biomedical and Clinical Diagnostic Systems XII, 89350I (27 February 2014); doi: 10.1117/12.2041092
Show Author Affiliations
Zhiwu Zhang, Univ. of Science and Technology of China (China)
Wenqi Ren, Univ. of Science and Technology of China (China)
Zelin Yu, Univ. of Science and Technology of China (China)
Shiwu Zhang, Univ. of Science and Technology of China (China)
Ting Yue, Univ. of Science and Technology of China (China)
Ronald Xu, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)

Published in SPIE Proceedings Vol. 8935:
Advanced Biomedical and Clinical Diagnostic Systems XII
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest M.D., Editor(s)

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