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Proceedings Paper

Effect of simvastatin versus low level laser therapy (LLLT) on bone regeneration in rabbit's tibia
Author(s): Mostafa E. Gheith; Maggie A. Khairy
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Paper Abstract

Simvastatin is a cholesterol lowering drug which proved effective on promoting bone healing. Recently low level laser therapy (LLLT) proved its effect as a biostimulator promoting bone regeneration. This study aims to compare the effect of both Simvastatin versus low level laser on bone healing in surgically created bone defects in rabbit’s tibia. Material and methods: The study included 12 New Zealand white rabbits. Three successive 3mm defects were created in rabbits tibia first defect was left as control, second defect was filled with Simvastatin while the third defect was acted on with Low Level Laser (optical fiber 320micrometer). Rabbits were sacrificed after 48 hours, 1 week and 2 weeks intervals. Histopathology was conducted on the three defects Results: The histopathologic studies showed that the bony defects treated with the Low Level Laser showed superior healing patterns and bone regeneration than those treated with Simvastatin. While the control defect showed the least healing pattern.

Paper Details

Date Published: 18 February 2014
PDF: 9 pages
Proc. SPIE 8929, Lasers in Dentistry XX, 89290J (18 February 2014); doi: 10.1117/12.2036100
Show Author Affiliations
Mostafa E. Gheith, Cairo Univ. (Egypt)
Maggie A. Khairy, October Univ. for Modern Science and Arts (Egypt)

Published in SPIE Proceedings Vol. 8929:
Lasers in Dentistry XX
Peter Rechmann; Daniel Fried, Editor(s)

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