We present a polymer optical waveguide integration technology for the detection of nanoparticles in an evanescent field based biosensor. In the proposed biosensor concept, super-paramagnetic nanoparticles are used as optical contrast labels. The nanoparticles capture target molecules from a sample fluid and bind to the sensor surface with biological specificity. The surface-bound nanoparticles are then detected using frustration of an evanescent field. In the current paper we elaborate on the polymer waveguides which are used to generate a well-defined optical field for nanoparticle detection.

Date Published: 20 February 2014
PDF: 7 pages
Proc. SPIE 8954, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI, 89540Q (20 February 2014); doi: 10.1117/12.2036072

Published in SPIE Proceedings Vol. 8954:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)