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Proceedings Paper

Gx1-conjugated endostar nanoparticle: a new drug delivery system for anti-colorectal cancer in vivo
Author(s): Qian Zhang; Yang Du; Yaqian Li; Xiaolong Liang; Xin Yang; Jie Tian
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Paper Abstract

In this study we describe a new theranostic nanostytem to combine those functions together. GX1, the peptide identified by phage display technology, is a tumor vasculature endothelium specific ligand. Endostar, a novel recombinant human endostatin, has been proved to inhibit tumor angiogenesis. In this study, Endostar-loaded PLA nanoparticles (EPNPs) were first prepared, and then GX1 was coupled to the surface of EPNPs for targeting therapy, last a near infrared (NIR) dye IRDye 800CW was conjugated to the surface of EPNPs for monitoring the biodistributon. This GX1-EPNPs-NIR dye IRDye 800CW (GEN) multifunction drug delivery system not only facilitates efficient delivery of chemotherapeutic agents to tumor site, while minimizing systemic toxicity and side effects, but also enables to real time monitor tumor targeting in vivo. Compare to the Endostar and EPNPs, the GEN inhibited the subcutaneous colon tumor more obviously both in tumor volume and bioluminescence imaging (BLI) light intensity during the 10 days drug treatment.

Paper Details

Date Published: 7 March 2014
PDF: 7 pages
Proc. SPIE 8956, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI, 895606 (7 March 2014); doi: 10.1117/12.2035910
Show Author Affiliations
Qian Zhang, Xidian Univ. (China)
Yang Du, Institute of Automation (China)
Yaqian Li, Harbin Univ. of Science and Technology (China)
Xiaolong Liang, Peking Univ. (China)
Xin Yang, Institute of Automation (China)
Jie Tian, Xidian Univ. (China)
Institute of Automation (China)

Published in SPIE Proceedings Vol. 8956:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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